Blockchain Adoption in Healthcare: Enhancing Interoperability, Security and Data Exchange

Keywords: Blockchain Technology, Healthcare Interoperability, Data Exchange, Privacy and Security

Abstract

Fragmented data across the healthcare industry increasingly impedes interoperability, compromises data security, and ultimately interferes with safe and quality patient care delivery. This research introduces a framework that uses blockchain technology to enhance interoperability and data exchange in healthcare environments. Leveraging qualitative methods,semi-structured interviews were held with fifteen health care practitioners at various facilities who gave their insights and perceptions of data sharing and blockchain technology. The findings were thematic and conceptualized through the Technology Acceptance Model, focusing on perceived ease of use and perceived usefulness, and the Technology-Organization-Environment framework that examined organizational support and regulatory compliance.  Thematic analysis identified four main themes, including (i) factors influencing adoption: ease of use with four participants, usefulness with three participants, organizational support with two participants, regulatory compliance with two participants, and technical infrastructure with two participants. (ii)Application areas included patient data management, billing and payment, and remote patient monitoring; (iii) benefits such as a more effective decentralized system, safer storage of data, and patient empowerment. (iv)Challenges included privacy concerns, the costs of implementation and system failure, and patients' knowledge and stakeholders' digital literacy. The findings suggested that stakeholders knew the potential disruption to any blockchain system. However, major issues needed to be addressed before implementation. This research expands the conversation about innovative solutions to health care interoperability. It exposes potential ways to address the challenges to adoption. Recommendations for future research include examining the scalability and integration of blockchain technology across different healthcare environments and addressing the pressing need for empirical evidence regarding its real-world applications and impacts.

Downloads

Download data is not yet available.

Author Biography

Belinda Ndlovu, National University of Science and Technology

Senior Lecturer Department of Informatics and Analytics.

References

D. M. Walker, W. L. Tarver, P. Jonnalagadda, L. Ranbom, E. W. Ford, and S. Rahurkar, “Perspectives on Challenges and Opportunities for Interoperability: Findings From Key Informant Interviews With Stakeholders in Ohio.,” JMIR Med. informatics, vol. 11, p. e43848, Feb. 2023, doi: 10.2196/43848.

M. A. Saberi, H. Mcheick, and M. Adda, “From Data Silos to Health Records Without Borders: A Systematic Survey on Patient-Centered Data Interoperability,” Inf., vol. 16, no. 2, pp. 1–31, 2025, doi: 10.3390/info16020106.

J. S. S. Mole and R. S. Shaji, “Ethereum blockchain for electronic health records: securing and streamlining patient management,” Front. Med., vol. 11, 2024, doi: 10.3389/fmed.2024.1434474.

R. Sibanda, B. Ndlovu, S. Dube, and K. Maguraushe, “Towards Health 4 . 0 : Blockchain-Based Electronic Health Record for Care Coordination,” pp. 712–720, 2024, doi: 10.34190/ecie.19.1.2606.

F. A. Reegu et al., “Blockchain-Based Framework for Interoperable Electronic Health Records for an Improved Healthcare System,” Sustain., vol. 15, no. 8, Apr. 2023, doi: 10.3390/su15086337.

A. Ademola, C. George, and G. Mapp, “Addressing the Interoperability of Electronic Health Records: Proposing the TASSIPS Framework,” Preprints, 2024.

J. Carlos Ferreira, L. B. Elvas, R. Correia, and M. Mascarenhas, “Enhancing EHR Interoperability and Security through Distributed Ledger Technology: A Review,” Healthcare (Switzerland), vol. 12, no. 19. Multidisciplinary Digital Publishing Institute (MDPI), Oct. 2024, doi: 10.3390/healthcare12191967.

H. Fatoum, S. Hanna, J. D. Halamka, D. C. Sicker, P. Spangenberg, and S. K. Hashmi, “Blockchain integration with digital technology and the future of health care ecosystems: Systematic review,” Journal of Medical Internet Research, vol. 23, no. 11. JMIR Publications Inc., Nov. 2021, doi: 10.2196/19846.

M. B. Horton et al., “Practice Guidelines for Ocular Telehealth-Diabetic Retinopathy, Third Edition,” Telemed. J. E. Health., vol. 26, no. 4, pp. 495–543, 2020, doi: 10.1089/tmj.2020.0006.

A. Solanke, “Blockchain Implementation for Enterprise Data Integrity : Distributed Ledger Strategies for Supply Chain Transparency and Trustworthy Data Abstract :,” no. March, 2025.

B. L. Jimma and D. B. Enyew, “Barriers to the acceptance of electronic medical records from the perspective of physicians and nurses:A scoping review,” Informatics Med. Unlocked, vol. 31, no. May, p. 100991, 2022, doi: 10.1016/j.imu.2022.100991.

N. Ncube, B. Mutunhu, and K. Sibanda, “Land Registry Using a Distributed Ledger,” in 2022 IST-Africa Conference, IST-Africa 2022, 2022, pp. 1–7, doi: 10.23919/IST-Africa56635.2022.9845584.

P. K. Ghosh, A. Chakraborty, M. Hasan, K. Rashid, and A. H. Siddique, “Blockchain Application in Healthcare Systems: A Review,” Systems, vol. 11, no. 1, 2023, doi: 10.3390/systems11010038.

Vimbai Alice Muderere, Belinda Ndlovu, and Kudakwashe Maguraushe, “Framework for Enhancing Interoperability, Data Exchange, and Security in Healthcare through Blockchain Technology,” Indones. J. Comput. Sci., vol. 12, no. 2, pp. 284–301, 2023, doi: 10.33022/ijcs.v14i4.4950.

N. N. Basil, S. Ambe, C. Ekhator, and E. Fonkem, “Health Records Database and Inherent Security Concerns: A Review of the Literature,” Cureus, 2022, doi: 10.7759/cureus.30168.

N. K. Mensah et al., “Health Professionals’ Ethical, Security, and Patient Safety Concerns Using Digital Health Technologies: A Mixed Method Research Study,” Heal. Serv. Insights, vol. 17, 2024, doi: 10.1177/11786329241303379.

A. Gedikci Ondogan, M. Sargin, and K. Canoz, “Use of electronic medical records in the digital healthcare system and its role in communication and medical information sharing among healthcare professionals,” Informatics Med. Unlocked, vol. 42, no. October, p. 101373, 2023, doi: 10.1016/j.imu.2023.101373.

S. Upadhye, S. Uparkar, A. Bhave, and P. O. Bagde, “Optimism or Pessimism: Is Blockchain Technology Helping the Healthcare Industry?,” 2022, doi: 10.1109/ICBDS53701.2022.9935891.

F. M. AbdelSalam, “Blockchain Revolutionizing Healthcare Industry: A Systematic Review of Blockchain Technology Benefits and Threats.,” Perspect. Heal. Inf. Manag., vol. 20, no. 3, pp. 1–19, 2023.

B. Mutunhu, B. Chipangura, and H. Twinomurinzi, “Internet of Things in the Monitoring of Diabetes: A Systematic Review,” Int. J. Heal. Syst. Transl. Med., vol. 2, no. 1, pp. 1–20, 2022, doi: 10.4018/IJHSTM.300336.

H. Taherdoost, “A Critical Review of Blockchain Acceptance Models—Blockchain Technology Adoption Frameworks and Applications,” Computers, vol. 11, no. 2, 2022, doi: 10.3390/computers11020024.

M. A. Bazel, F. Mohammed, M. Ahmad, A. O. Baarimah, and T. Al Maskari, “Blockchain technology adoption in healthcare: an integrated model,” Sci. Rep., vol. 15, no. 1, pp. 1–26, 2025, doi: 10.1038/s41598-025-95253-x.

M. Sciarelli, A. Prisco, M. H. Gheith, and V. Muto, “Factors affecting the adoption of blockchain technology in innovative Italian companies: an extended TAM approach,” J. Strateg. Manag., vol. 15, no. 3, pp. 495–507, 2022, doi: 10.1108/JSMA-02-2021-0054.

Z. A. Al-Sulami, N. Ali, and R. Ramli, “Blockchain adoption in Healthcare: Models, Challenges, and Future Work,” Basrah Res. Sci., vol. 49.2, no. 2, pp. 79–93, 2023, doi: 10.56714/bjrs.49.2.8.

J. D. Bryan and T. Zuva, “A Review on TAM and TOE Framework Progression and How These Models Int egrate,” Adv. Sci. Technol. Eng. Syst. J., vol. 6, no. 3, pp. 137–145, 2021, doi: 10.25046/aj060316.

A. Haleem, M. Javaid, R. P. Singh, R. Suman, and S. Rab, “Blockchain technology applications in healthcare: An overview,” Int. J. Intell. Networks, vol. 2, no. May, pp. 130–139, 2021, doi: 10.1016/j.ijin.2021.09.005.

J. Chaloner et al., “A qualitative study exploring healthcare workers’ lived experiences of the impacts of COVID-19 policies and guidelines on maternal and reproductive healthcare services in the United Kingdom.,” Eur. J. midwifery, vol. 7, p. 30, 2023, doi: 10.18332/ejm/171802.

J. Pyo, W. Lee, E. Y. Choi, S. G. Jang, and M. Ock, “Qualitative Research in Healthcare: Necessity and Characteristics,” J. Prev. Med. Public Heal., vol. 56, no. 1, pp. 12–20, 2023, doi: 10.3961/jpmph.22.451.

V. Braun and V. Clarke, “Thematic analysis.,” APA Handb. Res. methods Psychol. Vol 2 Res. Des. Quant. Qual. Neuropsychol. Biol., vol. 2, pp. 57–71, 2012, doi: 10.1037/13620-004.

I. Abu-elezz, A. Hassan, A. Nazeemudeen, M. Househ, and A. Abd-alrazaq, “The benefits and threats of blockchain technology in healthcare: A scoping review,” International Journal of Medical Informatics, vol. 142. Elsevier Ireland Ltd, Oct. 2020, doi: 10.1016/j.ijmedinf.2020.104246.

H. Taherdoost, “The Role of Blockchain in Medical Data Sharing,” Cryptography, vol. 7, no. 3, pp. 1–20, 2023, doi: 10.3390/cryptography7030036.

M. Attaran, “Blockchain technology in healthcare: Challenges and opportunities,” International Journal of Healthcare Management, vol. 15, no. 1. Taylor and Francis Ltd., pp. 70–83, 2022, doi: 10.1080/20479700.2020.1843887.

T. E. White, W. B. Wong, D. Janowiak, and L. H. Hilborne, “Strategies for laboratory professionals to drive laboratory stewardship,” Pract. Lab. Med., vol. 26, no. April, p. e00249, 2021, doi: 10.1016/j.plabm.2021.e00249.

O. Karneli, “The Role of Adhocratic Leadership in Facing the Changing Business Environment,” J. Contemp. Adm. Manag., vol. 1, no. 2, pp. 77–83, 2023, doi: 10.61100/adman.v1i2.26.

A. S. George, “Partners Universal Innovative Research Publication ( PUIRP ) India ’ s Ascent as the Global Epicenter of Artificial Intelligence Partners Universal Innovative Research Publication ( PUIRP ),” no. February, pp. 1–15, 2024, doi: 10.5281/zenodo.10936490.

M. Javaid, A. Haleem, R. P. Singh, R. Suman, and S. Khan, “A review of Blockchain Technology applications for financial services,” BenchCouncil Trans. Benchmarks, Stand. Eval., vol. 2, no. 3, p. 100073, 2022, doi: 10.1016/j.tbench.2022.100073.

R. Brandín and S. Abrishami, “Information traceability platforms for asset data lifecycle: blockchain-based technologies,” Smart Sustain. Built Environ., vol. 10, no. 3, pp. 364–386, 2021, doi: 10.1108/SASBE-03-2021-0042.

S. M. Williamson and V. Prybutok, “Balancing Privacy and Progress: A Review of Privacy Challenges, Systemic Oversight, and Patient Perceptions in AI-Driven Healthcare,” Appl. Sci., vol. 14, no. 2, p. 675, 2024, doi: 10.3390/app14020675.

R. Jabbar, N. Fetais, M. Krichen, and K. Barkaoui, “Blockchain technology for healthcare: Enhancing shared electronic health record interoperability and integrity,” in 2020 IEEE International Conference on Informatics, IoT, and Enabling Technologies, ICIoT 2020, Feb. 2020, pp. 310–317, doi: 10.1109/ICIoT48696.2020.9089570.

S. Saratkar, M. Langote, A. Chaudhari, T. Thute, R. Raut, and G. Thakre, “Enhancing Healthcare: Incorporating Blockchain into Electronic Health Records,” in 7th International Conference on Inventive Computation Technologies, ICICT 2024, 2024, pp. 1546–1551, doi: 10.1109/ICICT60155.2024.10544952.

R. Raj and S. P. Raja, “Revolutionizing Healthcare: Blockchain’s Transformative Applications for Data Security, Privacy, and Interoperability,” 2024, doi: 10.1109/I2CT61223.2024.10544066.

S. Ramzan, A. Aqdus, V. Ravi, D. Koundal, R. Amin, and M. A. Al Ghamdi, “Healthcare Applications Using Blockchain Technology: Motivations and Challenges,” IEEE Trans. Eng. Manag., vol. 70, no. 8, pp. 2874–2890, Aug. 2023, doi: 10.1109/TEM.2022.3189734.

C. Daah, A. Qureshi, I. Awan, and S. Konur, “Enhancing Zero Trust Models in the Financial Industry through Blockchain Integration: A Proposed Framework,” Electron., vol. 13, no. 5, 2024, doi: 10.3390/electronics13050865.

D. Singh, S. Monga, S. Tanwar, W. C. Hong, R. Sharma, and Y. L. He, “Adoption of Blockchain Technology in Healthcare: Challenges, Solutions, and Comparisons,” Applied Sciences (Switzerland), vol. 13, no. 4. MDPI, Feb. 2023, doi: 10.3390/app13042380.

M. Wosny, L. M. Strasser, and J. Hastings, “Experience of Health Care Professionals Using Digital Tools in the Hospital: Qualitative Systematic Review,” JMIR Hum. Factors, vol. 10, no. 1, pp. 1–21, 2023, doi: 10.2196/50357.

A. A. Kawu, L. Hederman, J. Doyle, and D. O’Sullivan, “Patient generated health data and electronic health record integration, governance and socio-technical issues: A narrative review,” Informatics Med. Unlocked, vol. 37, no. September 2022, p. 101153, 2023, doi: 10.1016/j.imu.2022.101153.

L. Theodorakopoulos, A. Theodoropoulou, and C. Halkiopoulos, “Enhancing Decentralized Decision-Making with Big Data and Blockchain Technology: A Comprehensive Review,” Appl. Sci., vol. 14, no. 16, 2024, doi: 10.3390/app14167007.

D. Bhati, M. S. Deogade, and D. Kanyal, “Improving Patient Outcomes Through Effective Hospital Administration: A Comprehensive Review,” Cureus, vol. 15, no. 10, 2023, doi: 10.7759/cureus.47731.

M. A. Al-Khasawneh, M. Faheem, A. A. Alarood, S. Habibullah, and A. Alzahrani, “A secure blockchain framework for healthcare records management systems,” Healthc. Technol. Lett., no. September, pp. 461–470, 2024, doi: 10.1049/htl2.12092.

P. Shojaei, E. Vlahu-Gjorgievska, and Y. W. Chow, “Security and Privacy of Technologies in Health Information Systems: A Systematic Literature Review,” Computers, vol. 13, no. 2, 2024, doi: 10.3390/computers13020041.

A. J, D. P. Isravel, K. M. Sagayam, B. Bhushan, Y. Sei, and J. Eunice, “Blockchain for healthcare systems: Architecture, security challenges, trends and future directions,” Journal of Network and Computer Applications, vol. 215. Academic Press, Jun. 2023, doi: 10.1016/j.jnca.2023.103633.

A. Ali et al., “Blockchain-Powered Healthcare Systems: Enhancing Scalability and Security with Hybrid Deep Learning,” Sensors, vol. 23, no. 18, pp. 1–33, 2023, doi: 10.3390/s23187740.

N. Ettaloui, S. Arezki, and T. Gadi, “Blockchain-Based Electronic Health Record: Systematic Literature Review,” Hum. Behav. Emerg. Technol., vol. 2024, no. 1, 2024, doi: 10.1155/hbe2/4734288.

A. Punia, P. Gulia, N. S. Gill, E. Ibeke, C. Iwendi, and P. K. Shukla, “A systematic review on blockchain-based access control systems in cloud environment,” J. Cloud Comput., vol. 13, no. 1, 2024, doi: 10.1186/s13677-024-00697-7.

S. Ben Othman and M. Getahun, “Leveraging blockchain and IoMT for secure and interoperable electronic health records,” Sci. Rep., vol. 15, no. 1, pp. 1–25, 2025, doi: 10.1038/s41598-025-95531-8.

M. S. B. Kasyapa and C. Vanmathi, “Blockchain integration in healthcare: a comprehensive investigation of use cases, performance issues, and mitigation strategies,” Frontiers in Digital Health, vol. 6. Frontiers Media SA, 2024, doi: 10.3389/fdgth.2024.1359858.

Z. Wenhua, F. Qamar, T. A. N. Abdali, R. Hassan, S. T. A. Jafri, and Q. N. Nguyen, “Blockchain Technology: Security Issues, Healthcare Applications, Challenges and Future Trends,” Electron., vol. 12, no. 3, 2023, doi: 10.3390/electronics12030546.

H. Sahu, S. Choudhari, and S. Chakole, “The Use of Blockchain Technology in Public Health: Lessons Learned,” Cureus, Jun. 2024, doi: 10.7759/cureus.63198.

Y. Blockchain- et al., “Citation: Blockchain-Based Healthcare Records Management Framework: Enhancing Security, Privacy, and Interoperability,” pp. 1–19, 2024.

Y. Han, Y. Zhang, and S. H. Vermund, “Blockchain Technology for Electronic Health Records,” Int. J. Environ. Res. Public Health, vol. 19, no. 23, Dec. 2022, doi: 10.3390/ijerph192315577.

H. Saeed et al., “Blockchain technology in healthcare: A systematic review,” PLoS One, vol. 17, no. 4 April, Apr. 2022, doi: 10.1371/journal.pone.0266462.

Y. Shynar et al., “Comprehensive Analysis of Blockchain Technology in the Healthcare Sector and Its Security Implications,” Int. J. E-Health Med. Commun., vol. 15, no. 1, 2025, doi: https://doi.org/10.4018/IJEHMC.372423.

G. Tripathi, M. A. Ahad, and G. Casalino, “A comprehensive review of blockchain technology: Underlying principles and historical background with future challenges,” Decis. Anal. J., vol. 9, no. October, p. 100344, 2023, doi: 10.1016/j.dajour.2023.100344.

P. Durneva, K. Cousins, and M. Chen, “The current state of research, challenges, and future research directions of blockchain technology in patient care: Systematic review,” Journal of Medical Internet Research, vol. 22, no. 7. JMIR Publications Inc., Jul. 2020, doi: 10.2196/18619.

A. Sepas, A. H. Bangash, O. Alraoui, K. El Emam, and A. El-Hussuna, “Algorithms to anonymize structured medical and healthcare data: A systematic review.,” Front. Bioinforma., vol. 2, p. 984807, 2022, doi: 10.3389/fbinf.2022.984807.

M. Faheem, M. A. Al-khasawneh, S. Habibullah, and A. Alzahrani, “A secure blockchain framework for healthcare records management systems,” no. September, pp. 461–470, 2024, doi: 10.1049/htl2.12092.

X. Zhang and R. Saltman, “Impact of Electronic Health Record Interoperability on Telehealth Service Outcomes,” JMIR Med. Informatics, vol. 10, no. 1, pp. 1–9, 2022, doi: 10.2196/31837.

M. Faheem, B. Raza, M. S. Bhutta, and S. H. H. Madni, “A blockchain-based resilient and secure framework for events monitoring and control in distributed renewable energy systems,” IET Blockchain, vol. 4, no. S1, pp. 644–658, 2024, doi: 10.1049/blc2.12081.

K. Maguraushe, “Development of a diagnostic instrument and privacy model for student personal information privacy perceptions at a Zimbabwean university,” pp. 1–383, 2021, [Online]. Available: http://hdl.handle.net/10500/27557.

K. Maguraushe, A. Da Veiga, and N. Martins, “Validation of an Information Privacy Perception Instrument at a Zimbabwean University,” in 14th International Symposium on Human Aspects of Information Security and Assurance (HAISA), 2020, pp. 300–314.

M. Bouke, A. Abdullah, S. ALshatebi, H. E. Atigh, and K. Cengiz, “African Union Convention on Cyber Security and Personal Data Protection: Challenges and Future Directions,” pp. 1–15, 2023.

S. S. Mohammed Abdul, “Navigating Blockchain’s Twin Challenges: Scalability and Regulatory Compliance,” Blockchains, vol. 2, no. 3, pp. 265–298, 2024, doi: 10.3390/blockchains2030013.

S. Talwar, A. Dhir, N. Islam, P. Kaur, and A. Almusharraf, “Resistance of multiple stakeholders to e-health innovations: Integration of fundamental insights and guiding research paths,” J. Bus. Res., vol. 166, no. June, p. 114135, 2023, doi: 10.1016/j.jbusres.2023.114135.

J. Piasecki and P. Y. Cheah, “Ownership of individual-level health data, data sharing, and data governance,” BMC Med. Ethics, vol. 23, no. 1, pp. 1–9, 2022, doi: 10.1186/s12910-022-00848-y.

S. Abdallah and N. Nizamuddin, “Blockchain-based solution for Pharma Supply Chain Industry,” Comput. Ind. Eng., vol. 177, p. 108997, 2023, doi: https://doi.org/10.1016/j.cie.2023.108997.

S. Porsdam Mann, J. Savulescu, P. Ravaud, and M. Benchoufi, “Blockchain, consent and prosent for medical research.,” J. Med. Ethics, vol. 47, no. 4, pp. 244–250, May 2020, doi: 10.1136/medethics-2019-105963.

G. Bahari, I. Mutambik, A. Almuqrin, and Z. H. Alharbi, “Trust: How It Affects the Use of Telemedicine in Improving Access to Assistive Technology to Enhance Healthcare Services.,” Risk Manag. Healthc. Policy, vol. 17, pp. 1859–1873, 2024, doi: 10.2147/RMHP.S469324.

W. Yang et al., “Adaptive Parallel Scheduling Scheme for Smart Contract,” Mathematics, vol. 12, no. 9, 2024, doi: 10.3390/math12091347.

P. Jhamba, B. Ndlovu, S. Dube, K.Maguraushe M. Muduva, and F. Jacqueline, “A Blockchain-based Patient Portal for Mental Health Management,” 2024, doi: 10.46254/AF05.20240251.

S. Sheela, A. A. Alsmady, K. Tanaraj, and I. Izani, “Navigating the Future: Blockchain’s Impact on Accounting and Auditing Practices,” Sustainability, vol. 15, no. 24, 2023, doi: 10.3390/su152416887.

H. B. Ncube, B. M. Ndlovu, K. Maguraushe and S. Dube, “Blockchain-Based Fraud Detection System for Healthcare Insurance Claims,” no. 2023, pp. 540–547, 2024, doi: 10.34190/ecie.19.1.2558.

Published
2025-09-30
Abstract views: 285 times
Download PDF: 160 times
How to Cite
Muderere, V., Ndlovu, B., & Maguraushe, K. (2025). Blockchain Adoption in Healthcare: Enhancing Interoperability, Security and Data Exchange. Journal of Information Systems and Informatics, 7(3), 2939-2977. https://doi.org/10.51519/journalisi.v7i3.1267
Section
Articles